Autoactivation of Procaspase-9 by Apaf-1-Mediated Oligomerization
نویسندگان
چکیده
منابع مشابه
Oligomerization and activation of caspase-9, induced by Apaf-1 CARD.
Apaf-1 facilitates the proteolytic activation of procaspase-9 and maintains the hyperactive state of the processed caspase-9. The underlying molecular mechanisms for these activities remain poorly characterized. Here we report that the isolated Apaf-1 caspase recruitment domain (CARD) forms a large hetero-oligomer with the active caspase-9. The catalytic activity of caspase-9 is significantly e...
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ژورنال
عنوان ژورنال: Molecular Cell
سال: 1998
ISSN: 1097-2765
DOI: 10.1016/s1097-2765(00)80095-7